
Family-Friendly rentals near Case Western Reserve University
Find and book unique family-friendly homes on Airbnb
Top-rated family-friendly rentals near Case Western Reserve University
Guests agree: these stays are highly rated for location, cleanliness, and more.

Little Italy 3, close to Cleveland Clinic, CWRU
Enjoy a uniquely styled experience at this boho-chic apartment in the heart of Little Italy. Exposed brick walls, hardwood floors, and wooden furnishings combine to give this apartment a boho-chic aesthetic. Enjoy dinner in the cozy kitchen and watch TV while relaxing on the comfortable sofa. One flight of stairs is leading up to the second floor (17 steps)The unit is on a quiet side street in walking distance to the heart of Little Italy (restaurants,cafes, shops).Free parking on premises(1car)

In the heart of Little Italy! Free Parking! 3BR-UP
Enjoy your stay at this centrally located - upper unit- in a two-family home in Little Italy. Apartment is complete with a well-equipped kitchen. The living room includes comfortable seating for 6, a smart TV, 3 poufs & coffee table - so that ALL may rest their feet from a long day, modern furnishings and a washer/dryer/linen closet. Each bedroom includes USB plugs in the lamps, alarm clocks with sound machines, blackout curtains, ceiling fans, Smart TVs, "ultra-quiet" ACs, desk, chair & mirror.

The Farmhouse - 1 Bdrm Apt in a Great Location
Welcome to this 2nd flr 1 bd/1 ba private apartment in a charming 1880s farmhouse located in a friendly walkable neighborhood. Full kitchen with all you need to make your own meals, washer/dryer and separate office inside the unit. Free off-street parking. You are only: 5 min walk to Starbucks, a variety of restaurants, bars, shops, trails 5-10 min drive to Cleveland Clinic, University Hospitals, Case Western, museums, parks, Little Italy and more 15 min drive to major attractions and Lake Erie

Historic Little Italy Garden Apartment
Stylish garden apartment. This retreat blends modern comfort with the vibrant cultural charm of Historic Little Italy. Steps away from shops, restaurants, and lively bars. Wade Oval Park is a nearby cultual hub, home to The Art & Natural History Museums and Botanical Gardens. Easy access to Case Western Reserve, Cleveland Clinic and University Hospital. Walk to the beautiful Lakeview Cemetary or take transit downtown to 4th street. Perfect for short or long stays. Book for a memorable time.

Walkable Little Italy Gem w/ King Bed | Near CWRU
Stay in Cleveland’s Little Italy area in a clean 2BR apartment with a king bedroom, queen bedroom, full kitchen, Wi-Fi, and Roku TV. Walk to neighborhood restaurants, bakeries, and coffee shops, with easy access to Case Western Reserve, Cleveland Institute of Music, Cleveland Clinic, University Hospitals, and University Circle. Ideal for up to 4 guests visiting for school, medical appointments, work, or a Cleveland getaway. ⚠️ See full description for temporary construction April - June 2026

"Historic Charm - Loft in the Heart of Cleveland"
This one-of-a-kind, luxury apartment in the heart of Cleveland’s vibrant Gateway District boasts a private rooftop patio & free parking! Located atop a beautifully restored 1880s-era building, this stunning 1200 sq ft walk-up loft offers the perfect blend of historic charm and modern luxury. With just a few short steps, you'll find yourself at Progressive Field and Rocket Arena, while most of Cleveland’s top attractions are within a 5-20 minute walk. Enjoy a 1st floor restaurant as well!

Mid-Century Modern Retreat in Little Italy
Nestled in the vibrant yet peaceful and safe Little Italy neighborhood of Cleveland, this newly remodeled Mid-Century Modern style 2bed/1bath Lower unit is within walking distance to the best Cleveland has to offer. Enjoy a stroll to Case Western Reserve University, University Circle, the Cleveland Museum of Art, Cleveland Botanical Garden, and more. Discover local shops, bakeries, and renowned restaurants that give Little Italy its charm. The RTA redline station is a five minute walk.

Cle Suites 1BR/1BA | 5 min Walk to Cle Clinic #6
Fully furnished luxury apartment that has been completely renovated combining old-time 19th century charm with modern amenities. Just move in with your suitcase! Within walking distance to the Cleveland Clinic Campus (5 min walk from main hospital). It’s also near University Hospitals, CWRU, Great University Circle, Downtown Cleveland, and Little Italy. This location is perfect for those receiving medical treatments and their families, doctors on rotation, travel nurses, and interns.

Rare Cleveland Apt: Little Italy! W/Sauna&Hot tub!
Fall in love with this charming, newly updated 1-bedroom, 1-bath lower unit triplex apartment situated in the heart of Little Italy, walking distance from University Circle, UH Hospital, Cleveland Museum of Art, Botanical Garden, Public Transportation and much more. Apartment is complete with a well-equipped kitchen, Smart TV, laptop workspace, and modern furnishings, this vacation/business rental delivers all the essentials so you can spend more time relaxing and exploring.

Stylish 1BD Condo I Minutes From Little Italy
Our apartment is ideally located near Cleveland Clinic, making it perfect for medical professionals, patients, and families. You’ll also be minutes from the Health Education Campus, Case Western Reserve University, University Hospitals, and the museums of University Circle. Enjoy a short drive to the charming Little Italy neighborhood, filled with authentic Italian restaurants, cafés, and bakeries, while downtown Cleveland is just 5 miles away for dining and entertainment.

2BR in Little Italy, 5 min walk to Case & UH
Enjoy a stylish experience at this centrally-located place in the heart of Little Italy. Newly renovated with a minimalist design. You are just down the street from restaurants, bakeries and bars. The RTA redline is also a two minute walk away, which takes you straight downtown as well as to the airport. Also within walking distance of Cleveland Clinic and University Circle. The apartment is located on the first floor. There is no private parking at the property.

Clean and Cozy Carriage House Getaway
Sunny and cozy carriage house in safe, historic neighborhood - perfectly appointed for overnight guests or extended stay visitors. Close proximity to Cleveland Clinic, Case Western, John Carroll University, Shaker Lakes & University Circle. Enjoy the charm of staying in this premier neighborhood with the comforts of home including updated kitchen, furnishings, bed/bedding and spa shower. Beautiful, safe, tree-lined street with private entrance and parking spot.
Popular amenities for family-friendly rentals near Case Western Reserve University
Family-friendly home rentals with a hot tub

HotTub+GameRoom+FencedBack+EV+PetsOK+Kings+KidLoft

Finland House CLE| Boutique Retreat with Hot Tub

Private 2 Level Apartment with Hot Tub in Tremont

Planes, Trains and Automobiles

Lux Penthouse Downtown Cleveland - Rooftop Hot Tub

Flats Social Club | City Getaway w/ Hot Tub

Groovy Cedar Chalet Forest View

THE TWIN HOMES #4 - dead center OHC
Family- and pet-friendly home rentals

Coventry Village -Hampshire Rd.- Upper

Sunny Studio II / Private home next to Ray's MTB

Gallery House | Near Clinic + Museums

Cottage52

Upscale & Beautiful 2 bedroom apartment

Walk to Cleveland Clinic | Modern 1BR | Parking

Historic Cleveland Heights Carriage House!

Cozy and Quiet Apartment
Family-friendly home rentals with a pool

Your home away from home!

Stylish Chic Downtown Apartment

Pool • Steps to Concert Venues • Stadiums • Views

Sleek DT Cleveland Apt at Skyline

Luxury Apt w/ Rooftop Pool, Hot Tub & Skyline View

Slow Burn | Urban Oasis Near Downtown CLE

Luxury Spa+Theater+Gameroom | CasaMora

Central Flat w/ Pool & Sauna • Gym • Heart of DT
Family-friendly home rentals with Wifi

Blue Historic House by Cle Clinic, CWRU, Museums

Sleeps 3 | Downtown & Museums Nearby

Private Suite by CLE Clinic - Room 1

Cozy Loft

Comfy 1B1B w/ Wi-Fi, Gym + Parking

Near hospitals colleges food bars w/garage space

Swanky Mid-Modern Hideaway-Walk to Restaurants

Easy Check-In 4 mins Cleveland Clinic CWRU Parking
Quick stats about family-friendly rentals near Case Western Reserve University

Total vacation rentals
Explore 40 vacation rentals in Case Western Reserve University

Nightly prices starting at
Case Western Reserve University vacation rentals start at $20 per night before taxes and fees

Verified guest reviews
Over 1,170 verified reviews to help you choose

Pet-friendly vacation rentals
Find 10 rentals that welcome pets

Rentals with dedicated workspaces
30 properties have a dedicated workspace

Wi-Fi availability
40 of Case Western Reserve University vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Case Western Reserve University rentals

4.8 Average rating
Case Western Reserve University stays are highly rated by guests—averaging 4.8 out of 5!
Destinations to explore
- Cuyahoga Valley National Park
- Rocket Mortgage FieldHouse
- Progressive Field
- Pro Football Hall of Fame
- Rock & Roll Hall of Fame
- Cleveland Browns Stadium
- Gervasi Vineyard
- Headlands Beach State Park
- Cleveland Metroparks Zoo
- Mosquito Lake State Park
- Punderson State Park
- Boston Mills
- Agora Theatre & Ballroom
- The Arcade Cleveland
- Laurentia Vineyard & Winery
- Cleveland Museum of Art
- Huntington Convention Center of Cleveland
- Cleveland Botanical Garden
- Crocker Park
- Edgewater Park Beach
- Playhouse Square
- Debonné Vineyards
- Cleveland Museum of Natural History
- JACK Cleveland Casino
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