
Guesthouse vacation rentals in Lee County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Lee County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

Waterfront Hideaway
This picturesque Airbnb is a hidden gem nestled along a canal, one minute boat ride to the Caloosahatchee River. The living room, bathed in natural light is perfect for taking in the scenic views. The spacious bedroom has a king-size bed, ensuring a night of blissful rest. The full kitchen is equipped with all modern appliances. Close to Sanibel & Fort Myers Beach. Bring your boat & dock it on the seawall, ready to set sail whenever your heart desires. Book now - your coastal paradise awaits!
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Perfect Place for your Vacations
This Guesthouse has everything you need for your vacation, it is central located, in a peaceful and safe neighborhood and have a very well distributed space. Its located few minutes from the Caloosahatche River and the beautiful beaches of the Gulf of Mexico, it includes bicycles, kayaks, umbrella, beach chairs, fishing rods and other items that will enhance your vacation. It is also very close to highly recommended restaurants, famous shops (walmart,Publix, McDonald) and other essential places.
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Hezekiah's 2 Story Guesthouse with Pool
Hezekiahs Guesthouse a perfect getaway in sunny SWFL! You will be staying in the guest house with a private entrance. This property has a living room and kitchenette downstairs and a spacious bedroom with master bathroom upstairs. This Airbnb is attached to our home. You will have access to the pool and our outside grill area. Complimentary coffee, water, soda and more.. Lots of nearby restaurants and shopping. Minutes away to Fort myers or Bonita beach, FGCU and RSW Airport and Hertz Arena.
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Private Guesthouse in Cape Coral +Laundry+King Bed
Fully remodeled, peaceful & centrally-located guest house. All private, no shared spaces. Fully fenced patio great for pets, smokers or just enjoy Florida weather with a glass of wine or a pint of beer. Outdoor table & chairs for dining under the stars. Many restaurants & supermarkets in a 5 mile radius. King Size Bed Full kitchen Washer and dryer. Long driveway with 2 Parking spaces or truck + trailer. Mini-split AC, Ceiling Fan. Text host for avail. $10 per hour early check-in & check-out
LocationCleanlinessKitchen

Cozy haven
Enjoy a stylish experience at this centrally-located place (close to beach) This brand new space has one bedroom with a king bed, closet and dresser, blow up queen bed mattress and pull out single couch along with additional seating. It has a tub/shower combo in the bathroom along with a washer and dryer. The fully equipped kitchen has anything you need. Has Patio/deck. Guesthouse is completely private but entrance is through the detached garage. You will have your own code to access all doors
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Charming Carriage House next to Edison Ford Estate
Wake up overlooking the gardens of the historic Edison Ford Estates before strolling into Art Deco Downtown Fort Myers for breakfast or an evening cocktail. This charming carriage house backs directly onto the famous Edison Ford Estates offering a peaceful, walkable setting full of Old Florida charm. Downtown's restaurants, bars and shops are a 20-minute walk away, or hop on the free trolley (Nov–May). The Caloosahatchee river just 3 blocks away SWF International Airport is 17 miles away.
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Get Away to the Mango Cottage
Nestled on the outskirts of Historic downtown Fort Myers abides the Mango Cottage overlooking the Caloosahatchee River. The sunsets are amazing. You will enjoy the luxurious linens on the King sized bed to the relaxing patio it will delight the senses. You will be able to enjoy the 60" flat screen Smart TV! . The cottage is complete with Keurig coffee maker, toaster, microwave/convection oven and grill outside. We are minutes from restaurants and night life. This is a NON-SMOKING property.
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Saltwater Pool • Canal Front • Kayaks Provided
In S Fort Myers. Relax by the saltwater pool, then launch kayaks or a two-person canoe from the pet-friendly fenced backyard to explore mangrove-lined canals. Drive 13 miles to Sanibel Island, 6 miles to Fort Myers Beach. Walk to Lakes Park/Wednesday Farmers Market or Castle Golf (mini golf). Bike trails nearby. Close to Publix, shops & restaurants. Private 1st-floor guest suite with private entry, 1 bed, 1 bath & full kitchen. Owners live upstairs. Convertible sofa for extra sleeping space.
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Sleep over the water- Boathouse with Private Dock
This 1920s boathouse offers a once-in-a-lifetime stay directly over Whiskey Creek, where the gentle sound of water beneath your feet lulls you to sleep. With a private entrance, dock and waterfront views, this isn't just a room--it is an unforgettable Florida experience. This boathouse has been ungraded with all modern conveniences and is centrally located close to downtown, restaurants and shopping. Sip your morning coffee on the dock as herons and bald eagles glide across the creek.
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Chameleon Guest Cabana
The 300 Sq Ft Cabana Studio Apartment with Separate full Bathroom!! The Cabana with mini fridge, microwave, Keurig and toaster is completely private and was built in 1925 and recently updated is tucked away in a lovely established and historic neighborhood very close (walking distance) to The Edison Ford Winter Estates. Downtown Ft. Myers is a walkable distance if you are accustomed to walking but may be a little far for some. The neighborhood is very safe and quiet. Safe Travels
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Central Modern Hidden Gem with pool
Location! Location! This is close distance to Deli, restaurants and supermarket . The house faces the canal with breathtaking views we have cameras facing the canal and pool area in order to protect you. This is only for 2 persons. No children or service dogs or comfort pets allowed. The price you see per night is the price including all the fees, before this you will see a price then at check out other fees were added on this listing the price you see is the real price.
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“Luxury Efficiency in San Carlos
Enjoy your stay in this brand-new, luxury efficiency located in the heart of San Carlos Park, FL. This modern space features a beautifully furnished master bedroom, a pristine restroom, and a fully equipped kitchen and living area. Perfect for a relaxing getaway, you’ll be just 20 minutes from some of Florida’s best beaches. Whether you’re here for business or leisure, this serene retreat offers comfort and convenience. Book now for a luxurious stay near the coast!
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Popular amenities for Lee County guesthouse rentals
Family-friendly guest house rentals

South Fort Myers close to FGCU and beaches
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Cozy Escape!
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Private Casita in Lehigh Acres • Parking
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Sun Spotters Pet Friendly, fully fenced yard
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Cozy Suite Near Historic River District & Beaches!
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Private Bungalow Ft Myers Home Near Beaches/FGCU
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Island Oasis
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Susie's Old Florida Cottage
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Guest house rentals with a patio

Julie’s Rivers Edge Retreat North Ft Myers
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1/1 Relaxing Retreat in Sunny Bonita Springs
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Beachside Living – Walk to the Water!
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Serene Studio Steps from the Water
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Cozy Guest Suite with Private Entrance
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Sand shack retreat canal w/pool
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Cozy Private Studio •Great location
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Adorable & spacious efficiency w/ full kitchen
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Guest house rentals with a washer and dryer

Private guest house—minutes to the best beaches!
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The Palmview Loft
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Adorable Estero Cottage - Heated Pool/Spa - Sauna
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Downtown Fort Myers Florida - Home Away From Home
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Barefoot Bungalow – Cozy 2 BR Beach Retreat
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3 bedroom 2 bath heated Pool Guest house
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Modern Independent Tiny House
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The Flamingo Guesthouse on CANAL
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