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House vacation rentals in Panama

Find and book unique houses on Airbnb

Top-rated house rentals in Panama

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Superhost
Home in Bocas del Toro
4.8 out of 5 average rating, 212 reviews

Bocas Beach House | Oceanfront Pier & Private Cove

Step back in time to this beachfront Bocas gem! This unique 4BR/2BA home sleeps up to 10. Features a waterfront porch, private pier, residents-only beach cove & free SUPs/snorkels. Inside: a full kitchen, breezy layout, and A/C in all bedrooms, each with its own sink! Layout: 3BR downstairs (includes a private BR with breakfast nook, plus a 2-Queen walkthrough/TV room leading to a kids/overflow room) and 1BR upstairs. Walk to dining & shops! Enjoy a secluded vibe just mins from town center.

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Guest favorite
Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.
Home in La Guaira
4.97 out of 5 average rating, 114 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

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Top guest favorite
Home in Costa Esmeralda
4.98 out of 5 average rating, 219 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

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Superhost
An outdoor area features a private plunge pool surrounded by wooden decking and sun loungers. A blue shade sail offers protection from the sun. Lush greenery and a vibrant blue fence enhance the tropical ambiance, with glimpses of the water visible in the background.
Home in Bastimentos Island
4.83 out of 5 average rating, 141 reviews

Spacious, Over the Water Home with Plunge Pool

Perched over the water in Bastimentos Bay, this well-appointed four bedroom and three bath single family home combines classic Caribbean architecture with modern sensabilities. With over 2,000 sq ft of comfortably furnished spaces, there’s room enough for eight adults to spend time together - or apart - in any weather. BBQ poolside, stargaze from the hammocks, fish off the dock, walk to restaurants, or flag down a water taxi from your private boat dock for the ten minute trip to Bocastown.

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Guest favorite
Aerial view of colorful houses and boats along the calm, clear waters of Saigon Bay. The scene captures the unique over-water construction, with lush greenery in the background and a sailboat moored at the docks.
Home in Colón Island
4.87 out of 5 average rating, 148 reviews

2 Bedroom Apartment with Panoramic Caribbean View

Manta Raya Apartment is a very luminous, well constructed 2 stories apartment over the water in "Saigon Bay" on Isla Colón, the main island of the archipelago of Bocas del Toro. With our unique location on the Isthmus of Isla Colón. we enjoy nice sea breezes from both sides of the Caribbean and breathtaking views especially during sunrise and sunset (see pictures). We are a 60 cent taxi ride or 5 minute bike ride from all downtown attractions and just enough out of town enjoy the serenity.

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Top guest favorite
A modern entrance is framed by vibrant landscaping, featuring various plants and flowers. A charming wooden bridge leads to the door, while a spiral staircase is visible on the side, inviting exploration of the upper level.
Home in Boquete
4.96 out of 5 average rating, 112 reviews

Spacious 3BR walking distance, close to everything

Enjoy the comfort of this spacious and centrally located private home, located just a two-minute walk from downtown Boquete. Spectacular design with 3 bedrooms, work area, comfortable living-dining room, fully equipped kitchen, bathroom with hot water and parking with electric gate. Beautiful views of the Boquete valley from the balconies and the lookout point. House surrounded by a bamboo forest just a few steps from the best restaurants and attractions, in a quiet environment.

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Superhost
A spacious outdoor area is presented, featuring a large covered porch supported by sturdy wooden beams. The architecture combines natural materials with open spaces. Surrounding greenery and well-maintained grass complement the inviting setting, providing a perfect backdrop for relaxation.
Home in El Valle de Antón
4.75 out of 5 average rating, 99 reviews

Casa de Campo

This unique house was inspired out of a US Mountain Home named "The Three Deers". As per our knowledge, no other house in our country has a balanced wood - cement - and steel-building foundations achieved here. Made from the best fine Bocas del Toro and Chiriqui's large hardwood pieces, we did not want to mimic any fake wood structures. Located in the central street of Anton Valley, most of your tourist or daily activities can be arranged within a very short walking distance.

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Guest favorite
Home in San Carlos
4.89 out of 5 average rating, 173 reviews

El Palmar, playa a 50 metros

Escucha las olas desde la privacidad de nuestra terraza y crea recuerdos inolvidables en este alojamiento único y familiar a pocos paso de la playa con piscina privada. El palmar es una comunidad tranquila con varios restaurantes disponibles a unos pasos de la casa. La propiedad esta totalmente cercada para la tranquilidad y seguridad de hijos y sus mascotas adicional tienes wifi, TV cable en ambas habitaciones y aires acondicionados en la sala comedor y en todas las recamaras

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Guest favorite
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del Maria
4.82 out of 5 average rating, 330 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

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Guest favorite
A serene outdoor deck is shown with two lounge chairs positioned to view the bay at sunset. Calm waters extend to the horizon, where sailboats can be seen. Lush potted plants frame the scene, enhancing the tranquil setting.
Home in Bocas del Toro District
4.93 out of 5 average rating, 275 reviews

Orange House - Over The Water Rentals

Enjoy golden sunsets across the bay from the Orange House at Over The Water Rentals. Home away from home in a tropical paradise. Relax on your outdoor lounge or explore the bay. The house has snorkel gear, SUP's & kayaks for guests to use for free. Located close to town & airport in a quiet local neighborhood. The house features a king size master bedroom & queen guest room, spacious hot water shower, handmade organic toiletries, fully equipped kitchen & high speed wifi

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Superhost
A tranquil dipping pool is framed by lush greenery, featuring white loungers and a large umbrella for shade. The pool area exudes a serene vibe with vibrant bougainvillea in the background, enhancing the inviting outdoor space.
Home in Taboga Island
4.94 out of 5 average rating, 221 reviews

Casa Rosie - Dream Home on Tabogá Island

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

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Guest favorite
Home in Altos del Maria
4.76 out of 5 average rating, 160 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

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