Townhome vacation rentals in Pickens County

4.96 out of 5 average rating, 53 reviews

Amenity Rich Keowee Resort - 25 min to Clemson

Enjoy the Best of Both Worlds in our spacious 4-bedroom, 3-bath townhome in the gated Keowee Key Resort. Where lake life, mountain views, and resort amenities come together for the perfect getaway. Spread over three levels with two living rooms and two sunrooms, the home offers plenty of space for families, couples, or friends traveling together. When you're visiting Lake Keowee, Clemson University, or the Blue Ridge Mountains, this home is a comfortable base for both adventure and relaxation.

FamilyValueCleanliness

Top guest favorite

The entrance of a modern resort building is framed by a striking architectural design featuring a large overhanging roof and stone accents. Steps lead up to the glass doors, while landscaped greenery complements the exterior.

5 out of 5 average rating, 80 reviews

Resort Pool & Spa 3BR 3BTH w Loft, Family Gameroom

Escape to this spacious three-story, family-friendly home w bedrooms, baths, and decks on each level—perfect for large families (sleeps 9). Pack ’n Play available, easy front-door parking, & access to resort pools, spa, and sauna included. It's a professionally cleaned, dog-friendly 3BR, 3BA townhome w loft/3 living spaces. Enjoy wooded rolling hills w wildlife, resort amenities (some activities like golf or boat rentals have fees), ping-pong, board games, and a deck fireplace under the stars.

FamilyLocationCleanliness

4.93 out of 5 average rating, 14 reviews

Townhouse in Easley

Walk to Silos | 2BR 2.5BA Townhome + Chef Kitchen

Game-day energy, downtown charm, and your own three-level hideaway—less than 15 minutes from Greenville and 30 minutes from Clemson. Stretch out over king and queen suites, sip coffee on a private balcony, and stroll five minute walk to The Silos food hall before hopping on the Doodle Trail. Welcome to The Bosie, where relaxing weekends and action-packed adventures. Perfect location for game weekends & family visits w/ college kids and business travel! Book your stay before the calendar fills!

LocationFamilyIndoor spaces

A two-story townhouse is depicted, featuring a combination of beige siding and dark trim. Large windows allow ample natural light, and a red door adds a pop of color. The surrounding landscape includes a small lawn with trees, showcasing autumn foliage.

5 out of 5 average rating, 8 reviews

Brand New Build Clemson Retreat 3br/3bath sleeps 8

This is a new build, two story townhouse. Comfortably sleeps 8. All new furnishings. Kitchen has all that you need to host a football weekend, graduation party or special dinner. All 3 bedrooms have en-suite full bathrooms. Sleeper sofa has Queen gel foam mattress. Kitchen fully stocked. Walking distance to Clemson, and Botanical Gardens. Short drive to restaurants in Patrick Square downtown Clemson and Pendelton. Two parking spaces assigned to house. Truly great location!

LocationNearbyAccuracy

A spacious living area is furnished with comfortable gray sofas and a round coffee table, creating an inviting space. Natural light filters through large windows, illuminating a dining area with wooden chairs. A serene landscape photograph decorates the wall, enhancing the room’s calming ambiance.

4.71 out of 5 average rating, 14 reviews

Fun Lake Keowee TownHse Golf Tennis Picklball Pool

A lush serene setting of trees, walking paths and nature surround this 3 level townhome within the gates of Keowee Key. You will have quick access to Lake Keowee (2 marinas with kayak and boat launch and boat rentals) Pickle Ball and Tennis courts at the Fitness Center (some additional fees may apply), nearby golf and indoor and outdoor pools. This home is available as a dedicated rental property. The owners do not keep any of their personal items in the home.

LocationCleanlinessGrill

An open-concept living area features large windows allowing natural light to fill the space. Seating is arranged with a comfortable sofa and accent chairs surrounding a coffee table. A dining table with chairs is positioned near the windows, enhancing the airy atmosphere.

Townhouse in Central

5 out of 5 average rating, 3 reviews

5 Mi to Memorial Stadium & Beach: Modern Townhome

Recently Built | Dine Al Fresco Reconnect with family or friends and experience the best of Central, South Carolina, when you stay at this airy vacation rental! Tour Clemson’s vibrant campus, cheer on the Clemson Tigers, or simply soak up the sun along Lake Hartwell while the kids splash around in the water. Staying inside? Boasting 3 bedrooms, 2.5 bathrooms, an open-concept living area, and 2,500 square feet, this townhome provides plenty of space for everyone!

LocationIndoor spacesKitchen

A large outdoor swimming pool is set against a scenic lakeside backdrop, surrounded by lounge chairs. The water glimmers in sunlight, with trees lining the perimeter. Nearby, a marina with docked boats and a parking area is visible.

5 out of 5 average rating, 12 reviews

Walk to Lake Keowee: Salem Townhome w/ Deck

Walk to Private Beach | Fireplace | Newly Renovated | 10 Mi to Clemson Escape to this 4-bedroom, 3-bath vacation rental in Salem! Perfect for families, this townhome offers ample space to unwind after exploring Lake Keowee or Table Rock State Park. With a full kitchen and access to community amenities, this townhome has everything you need for a memorable retreat! Be sure to relax by the community pool or play a round of golf before cozying up by the fireplace!

LocationFamilyComfort

The exterior of a two-story townhouse is showcased, featuring blue-gray siding and contrasting black shutters. A bright yellow front door is positioned above a small mat, while a two-car garage with white doors is seen on the right. Landscaping includes dark mulch and small plants.

Townhouse in Easley

5 out of 5 average rating, 3 reviews

Exclusive Luxury Escape

Welcome to this cozy place in Easley, SC—perfectly located between Clemson and Greenville! Just 20 minutes from Clemson University and downtown Greenville, this space is ideal for college visits, game days, or exploring the Upstate. Enjoy a quiet, comfortable stay with modern amenities and easy access to local dining, shopping, and outdoor activities. Whether you're here for a Tigers game or a weekend getaway, our home offers the perfect base for your adventure.

LocationValueQuiet

5 out of 5 average rating, 8 reviews

Townhouse in Seneca

Boat Dock: Lake-View Retreat 5 Mi to Dtwn Clemson

Whether you're here for a relaxing lakefront getaway or to cheer on the Tigers, this impressive Seneca house is the perfect choice for you! Ideally situated on a private lot of nearly one acre on picturesque Lake Hartwell, this vacation rental boasts ample deck space, three screened porches, and a media room perfect for watching the big game. You'll love being within four miles of Clemson University, museums, parks, shops, restaurants, and more!

FamilyLocationView

Superhost

The exterior of the townhouse features a neutral brown wood paneling along with a brick chimney. A welcoming front porch with white railings leads up to the front door. The surrounding area includes neatly trimmed bushes and a backdrop of greenery, indicating a peaceful community setting.

4.88 out of 5 average rating, 16 reviews

Rosehill Villa at Clemson Botanical Gardens

Newly renovated 4 bedroom 3.5 bathroom townhouse. Open concept kitchen, living room and dining room. Small deck located off the kitchen and dining room to relax with coffee. Bring the whole family to this great place with lots of room for fun. This property backs up to the Clemson Botanical Gardens and is a 5 minute drive to reach Memorial Stadium (football), Littlejohn Coliseum (basketball), all where the Tigers play.

LocationFamilyGetting around

A spacious outdoor dining area is furnished with a wooden table surrounded by blue chairs. A potted plant centers the table, while the backdrop features serene views of Lake Hartwell and lush green landscapes under a clear sky.

5 out of 5 average rating, 13 reviews

Slice of Heaven at the Clemson Dike

A Slice of Heaven at the Clemson Dike is truly a unique and special location with incredible views of Lake Hartwell. Walk to Clemson`s campus, Memorial Stadium, Doug Kingsmore Baseball Stadium and the new McWhorter Softball Stadium. Located just behind the Esso Club, this 4 bedroom 4 bath townhome with 3 levels is waiting for your group to enjoy a trip to Clemson!

ValueFamilySleep quality

Top guest favorite